ASCT1 (Slc1a4) transporter is a physiologic regulator of brain d-serine and neurodevelopment

d-serine is a physiologic coagonist of NMDA receptors, but little is known about the regulation of its synthesis and synaptic turnover. The amino acid exchangers ASCT1 (Slc1a4) and ASCT2 (Slc1a5) are candidates for regulating d-serine levels. Using ASCT1 and ASCT2 KO mice, we report that ASCT1, rath...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Kaplan, Eitan, Zubedat, Salman, Radzishevsky, Inna, Valenta, Alec C., Rechnitz, Ohad, Sason, Hagit, Sajrawi, Clara, Bodner, Oded, Konno, Kohtarou, Esaki, Kayoko, Derdikman, Dori, Yoshikawa, Takeo, Watanabe, Masahiko, Kennedy, Robert T., Billard, Jean-Marie, Avital, Avi, Wolosker, Herman
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156681/
https://ncbi.nlm.nih.gov/pubmed/30185558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722677115
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