RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype

Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper-activated cholesterol-biosynthesis program that is strongly linked to nuclear receptor RORγ, compared to estrogen receptor-positi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Cai, Demin, Wang, Junjian, Gao, Bei, Li, Jin, Wu, Feng, Zou, June X., Xu, Jianzhen, Jiang, Yuqian, Zou, Hongye, Huang, Zenghong, Borowsky, Alexander D., Bold, Richard J., Lara, Primo N., Li, Jian Jian, Chen, Xinbin, Lam, Kit S., To, Ka-Fai, Kung, Hsing-Jien, Fiehn, Oliver, Zhao, Ruqian, Evans, Ronald M., Chen, Hong-Wu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789042/
https://ncbi.nlm.nih.gov/pubmed/31604910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12529-3
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