Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes

Metabolic reprogramming such as the aerobic glycolysis or Warburg effect is well recognized as a common feature of tumorigenesis. However, molecular mechanisms underlying metabolic alterations for tumor therapeutic resistance are poorly understood. Through gene expression profiling analysis we found...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Wang, Junjian, Duan, Zhijian, Nugent, Zoann, Zou, June X., Borowsky, Alexander D., Zhang, Yanhong, Tepper, Clifford G., Li, Jian Jian, Fienh, Oliver, Xu, Jianzhen, Kung, Hsing-Jien, Murphy, Leigh, Chen, Hong-Wu
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7505026/
https://ncbi.nlm.nih.gov/pubmed/27164560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2016.05.004
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