ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer

The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants of AR overexpression in CRPC are poorly defined. Here we show that retinoid acid receptor-related orphan receptor γ (ROR-γ) is overexpressed and amplified in...

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Bibliografske podrobnosti
izdano v:Nat Med
Main Authors: Wang, Junjian, Zou, June X., Xue, Xiaoqian, Cai, Demin, Zhang, Yan, Duan, Zhijian, Xiang, Qiuping, Yang, Joy C., Louie, Maggie C., Borowsky, Alexander D., Gao, Allen C., Evans, Christopher P., Lam, Kit S., Xu, Jianzhen, Kung, Hsing-Jien, Evans, Ronald M., Xu, Yong, Chen, Hong-Wu
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030109/
https://ncbi.nlm.nih.gov/pubmed/27019329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4070
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