ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer

The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants of AR overexpression in CRPC are poorly defined. Here we show that retinoid acid receptor-related orphan receptor γ (ROR-γ) is overexpressed and amplified in...

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Publicado no:Nat Med
Main Authors: Wang, Junjian, Zou, June X., Xue, Xiaoqian, Cai, Demin, Zhang, Yan, Duan, Zhijian, Xiang, Qiuping, Yang, Joy C., Louie, Maggie C., Borowsky, Alexander D., Gao, Allen C., Evans, Christopher P., Lam, Kit S., Xu, Jianzhen, Kung, Hsing-Jien, Evans, Ronald M., Xu, Yong, Chen, Hong-Wu
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030109/
https://ncbi.nlm.nih.gov/pubmed/27019329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4070
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