Enhancing Autophagy Diminishes Aberrant Ca(2+) Homeostasis and Arrhythmogenesis in Aging Rabbit Hearts

AIM: Aging in humans is associated with a 10–40-fold greater incidence of sudden cardiac death from malignant tachyarrhythmia. We have reported that thiol oxidation of ryanodine receptors (RyR2s) by mitochondria-derived reactive oxygen species (mito-ROS) contributes to defective Ca(2+) homeostasis i...

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Detalles Bibliográficos
Publicado en:Front Physiol
Main Authors: Murphy, Kevin R., Baggett, Brett, Cooper, Leroy L., Lu, Yichun, O-Uchi, Jin, Sedivy, John M., Terentyev, Dmitry, Koren, Gideon
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Physiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6787934/
https://ncbi.nlm.nih.gov/pubmed/31636573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01277
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