Enhancing Autophagy Diminishes Aberrant Ca(2+) Homeostasis and Arrhythmogenesis in Aging Rabbit Hearts

AIM: Aging in humans is associated with a 10–40-fold greater incidence of sudden cardiac death from malignant tachyarrhythmia. We have reported that thiol oxidation of ryanodine receptors (RyR2s) by mitochondria-derived reactive oxygen species (mito-ROS) contributes to defective Ca(2+) homeostasis i...

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Vydáno v:Front Physiol
Hlavní autoři: Murphy, Kevin R., Baggett, Brett, Cooper, Leroy L., Lu, Yichun, O-Uchi, Jin, Sedivy, John M., Terentyev, Dmitry, Koren, Gideon
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6787934/
https://ncbi.nlm.nih.gov/pubmed/31636573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01277
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