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Zinc supplementation increases protein titer of recombinant CHO cells

In order to study the impact of zinc and copper on the titer levels of mAb and recombinant protein in CHO cells, the IgG-expressing (DP12) and EPO-expressing (SK15) cell lines were cultured in chemically defined media with increasing concentrations of either metal. Supplementation with 25 mg/l in CD...

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Detalhes bibliográficos
Publicado no:Cytotechnology
Main Authors: Capella Roca, Berta, Alarcón Miguez, Antonio, Keenan, Joanne, Suda, Srinivas, Barron, Niall, O’Gorman, Donal, Doolan, Padraig, Clynes, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6787129/
https://ncbi.nlm.nih.gov/pubmed/31396753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-019-00334-1
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