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Zinc supplementation increases protein titer of recombinant CHO cells

In order to study the impact of zinc and copper on the titer levels of mAb and recombinant protein in CHO cells, the IgG-expressing (DP12) and EPO-expressing (SK15) cell lines were cultured in chemically defined media with increasing concentrations of either metal. Supplementation with 25 mg/l in CD...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cytotechnology
Prif Awduron: Capella Roca, Berta, Alarcón Miguez, Antonio, Keenan, Joanne, Suda, Srinivas, Barron, Niall, O’Gorman, Donal, Doolan, Padraig, Clynes, Martin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Netherlands 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6787129/
https://ncbi.nlm.nih.gov/pubmed/31396753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-019-00334-1
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