4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue

Therapeutic increase of brown adipose tissue (BAT) thermogenesis is of great interest as BAT activation counteracts obesity and insulin resistance. Hyaluronan (HA) is a glycosaminoglycan, found in the extracellular matrix, which is synthesized by HA synthases (Has1/Has2/Has3) from sugar precursors a...

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Udgivet i:Nat Metab
Main Authors: Grandoch, Maria, Flögel, Ulrich, Virtue, Sam, Maier, Julia K., Jelenik, Tomas, Kohlmorgen, Christina, Feldmann, Kathrin, Ostendorf, Yanina, Castañeda, Tamara R., Zhou, Zhou, Yamaguchi, Yu, Nascimento, Emmani B.M., Sunkari, Vivekananda G., Goy, Christine, Kinzig, Martina, Sörgel, Fritz, Bollyky, Paul L., Schrauwen, Patrick, Al-Hasani, Hadi, Roden, Michael, Keipert, Susanne, Vidal-Puig, Antonio, Jastroch, Martin, Haendeler, Judith, Fischer, Jens W.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786893/
https://ncbi.nlm.nih.gov/pubmed/31602424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0055-6
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