Skin-specific knockdown of hyaluronan in mice by an optimized topical 4-methylumbelliferone formulation

Hyaluronan (HA) is abundant in the skin; while HA can be synthesized by the synthases (HAS1-3), HAS2 is the leading contributor. Dysregulation and accumulation of HA is implicated in the pathogenesis of diseases such as keloid scarring, lymphedema and metastatic melanoma. To understand how HA synthe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Drug Deliv
Prif Awduron: Steen, Emily H., Short, Walker D., Li, Hui, Parikh, Umang M., Blum, Alexander, Templeman, Natalie, Nagy, Nadine, Bollyky, Paul L., Keswani, Sundeep G., Balaji, Swathi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2021
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899664/
https://ncbi.nlm.nih.gov/pubmed/33605181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2021.1886376
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