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Skin-specific knockdown of hyaluronan in mice by an optimized topical 4-methylumbelliferone formulation
Hyaluronan (HA) is abundant in the skin; while HA can be synthesized by the synthases (HAS1-3), HAS2 is the leading contributor. Dysregulation and accumulation of HA is implicated in the pathogenesis of diseases such as keloid scarring, lymphedema and metastatic melanoma. To understand how HA synthe...
Guardat en:
| Publicat a: | Drug Deliv |
|---|---|
| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7899664/ https://ncbi.nlm.nih.gov/pubmed/33605181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2021.1886376 |
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