Skin-specific knockdown of hyaluronan in mice by an optimized topical 4-methylumbelliferone formulation

Hyaluronan (HA) is abundant in the skin; while HA can be synthesized by the synthases (HAS1-3), HAS2 is the leading contributor. Dysregulation and accumulation of HA is implicated in the pathogenesis of diseases such as keloid scarring, lymphedema and metastatic melanoma. To understand how HA synthe...

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Bibliografische gegevens
Gepubliceerd in:Drug Deliv
Hoofdauteurs: Steen, Emily H., Short, Walker D., Li, Hui, Parikh, Umang M., Blum, Alexander, Templeman, Natalie, Nagy, Nadine, Bollyky, Paul L., Keswani, Sundeep G., Balaji, Swathi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899664/
https://ncbi.nlm.nih.gov/pubmed/33605181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2021.1886376
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