Characteristics of Hyaluronan Synthesis Inhibition by 4-Methylumbelliferone in Orbital Fibroblasts

PURPOSE: Hyaluronan (HA) overproduction by orbital fibroblasts (OFs) is a major factor in the pathogenesis of Graves’ orbitopathy (GO). 4-methylumbelliferone (4-MU) is an inhibitor of HA synthesis in different cell types in vitro and has beneficial effects in animal models of autoimmune diseases. ME...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Galgoczi, Erika, Jeney, Florence, Katko, Monika, Erdei, Annamaria, Gazdag, Annamaria, Sira, Livia, Bodor, Miklos, Berta, Eszter, Ujhelyi, Bernadett, Steiber, Zita, Gyory, Ferenc, Nagy, Endre V.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2020
Assuntos:
Biochemistry and Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326567/
https://ncbi.nlm.nih.gov/pubmed/32084270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.2.27
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