Magnesium isoglycyrrhizinate ameliorates high fructose-induced liver fibrosis in rat by increasing miR-375-3p to suppress JAK2/STAT3 pathway and TGF-β1/Smad signaling

Increasing evidence has demonstrated that excessive fructose intake induces liver fibrosis. Epithelial–mesenchymal transition (EMT) driven by transforming growth factor-β1 (TGF-β1)/mothers against decapentaplegic homolog (Smad) signaling activation promotes the occurrence and development of liver fi...

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Publicat a:Acta Pharmacol Sin
Autors principals: Yang, Yan-zi, Zhao, Xiao-juan, Xu, Hong-jiang, Wang, Shan-chun, Pan, Ying, Wang, Shui-juan, Xu, Qiang, Jiao, Rui-qing, Gu, Hong-mei, Kong, Ling-dong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786319/
https://ncbi.nlm.nih.gov/pubmed/30568253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0194-4
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