Modeling monogenic diabetes using human ES cells reveals developmental and metabolic deficiencies caused by mutations in HNF1A

Human monogenic diabetes, caused by mutations in genes involved in beta cell development and function, has been a challenge to study because multiple mouse models have not fully recapitulated the human disease. Here, we use genome edited human embryonic stem cells to understand the most common form...

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Publicat a:Cell Stem Cell
Autors principals: Cardenas-Diaz, Fabian L, Osorio-Quintero, Catherine, Diaz-Miranda, Maria A, Kishore, Siddharth, Leavens, Karla, Jobaliya, Chintan, Stanescu, Diana, Ortiz-Gonzalez, Xilma, Yoon, Christine, Chen, Christopher S., Haliyur, Rachana, Brissova, Marcela, Powers, Alvin C., French, Deborah L., Gadue, Paul
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785828/
https://ncbi.nlm.nih.gov/pubmed/31374199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.07.007
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