GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells

Induced pluripotent stem cells were created from a pancreas agenesis patient with a mutation in GATA6. Using genome-editing technology, additional stem cell lines with mutations in both GATA6 alleles were generated and demonstrated a severe block in definitive endoderm induction, which could be resc...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Tiyaboonchai, Amita, Cardenas-Diaz, Fabian L., Ying, Lei, Maguire, Jean Ann, Sim, Xiuli, Jobaliya, Chintan, Gagne, Alyssa L., Kishore, Siddharth, Stanescu, Diana E., Hughes, Nkecha, De Leon, Diva D., French, Deborah L., Gadue, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355564/
https://ncbi.nlm.nih.gov/pubmed/28196690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.12.026
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados