GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells

Induced pluripotent stem cells were created from a pancreas agenesis patient with a mutation in GATA6. Using genome-editing technology, additional stem cell lines with mutations in both GATA6 alleles were generated and demonstrated a severe block in definitive endoderm induction, which could be resc...

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Bibliografiset tiedot
Julkaisussa:Stem Cell Reports
Päätekijät: Tiyaboonchai, Amita, Cardenas-Diaz, Fabian L., Ying, Lei, Maguire, Jean Ann, Sim, Xiuli, Jobaliya, Chintan, Gagne, Alyssa L., Kishore, Siddharth, Stanescu, Diana E., Hughes, Nkecha, De Leon, Diva D., French, Deborah L., Gadue, Paul
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355564/
https://ncbi.nlm.nih.gov/pubmed/28196690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.12.026
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