Hesperidin ameliorates bleomycin-induced experimental pulmonary fibrosis via inhibition of TGF-beta1/Smad3/AMPK and IkappaBalpha/NF-kappaB pathways

Bleomycin (BLM) is a chemotherapeutic agent which is associated with Idiopathic pulmonary fibrosis (IPF) due to its chronic administration. Hesperidin, a bioflavonoid has been reported to possess antioxidant, anti-inflammatory, wound healing, and antiapoptotic potential. To evaluate the therapeutic...

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Detalhes bibliográficos
Publicado no:EXCLI J
Main Authors: Zhou, Zheng, Kandhare, Amit D., Kandhare, Anwesha A., Bodhankar, Subhash L.
Formato: Artigo
Idioma:Inglês
Publicado em: Leibniz Research Centre for Working Environment and Human Factors 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785776/
https://ncbi.nlm.nih.gov/pubmed/31611754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17179/excli2019-1094
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