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An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha.
The potent transcriptional activities of Rel/NF-kappaB proteins are regulated in the cytoplasm and nucleus by the inhibitor, IkappaBalpha. The mechanism, by which IkappaBalpha can either sequester NF-kappaB in the cytoplasm or act as a nuclear post-induction repressor of NF-kappaB, is uncertain. We...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1999
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171731/ https://ncbi.nlm.nih.gov/pubmed/10581242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.23.6682 |
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