Bexarotene therapy ameliorates behavioral deficits and induces functional and molecular changes in very-old Triple Transgenic Mice model of Alzheimer´s disease

INTRODUCTION: Bexarotene, a retinoid X receptor agonist, improves cognition in murine models of Alzheimer’s disease (AD). This study evaluated the effects of bexarotene on pathological and electrophysiological changes in very old triple transgenic AD mice (3xTg-AD mice). METHODS: 24-month-old 3xTg-A...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Muñoz-Cabrera, Jonathan Mauricio, Sandoval-Hernández, Adrián Gabriel, Niño, Andrea, Báez, Tatiana, Bustos-Rangel, Angie, Cardona-Gómez, Gloria Patricia, Múnera, Alejandro, Arboleda, Gonzalo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785083/
https://ncbi.nlm.nih.gov/pubmed/31596896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0223578
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