Bexarotene therapy ameliorates behavioral deficits and induces functional and molecular changes in very-old Triple Transgenic Mice model of Alzheimer´s disease

INTRODUCTION: Bexarotene, a retinoid X receptor agonist, improves cognition in murine models of Alzheimer’s disease (AD). This study evaluated the effects of bexarotene on pathological and electrophysiological changes in very old triple transgenic AD mice (3xTg-AD mice). METHODS: 24-month-old 3xTg-A...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Muñoz-Cabrera, Jonathan Mauricio, Sandoval-Hernández, Adrián Gabriel, Niño, Andrea, Báez, Tatiana, Bustos-Rangel, Angie, Cardona-Gómez, Gloria Patricia, Múnera, Alejandro, Arboleda, Gonzalo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785083/
https://ncbi.nlm.nih.gov/pubmed/31596896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0223578
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