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Glucocorticoids oppose thymocyte negative selection by inhibiting Helios and Nur77

Glucocorticoid signaling in thymocytes shapes the T cell antigen receptor (TCR) repertoire by antagonizing thymocyte negative selection. The transcription factors Nur77 and Helios, which are upregulated in TCR-signaled thymocytes, have been implicated in negative selection. Here we found that glucoc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Immunol
Prif Awduron: Mittelstadt, Paul R., Taves, Matthew D., Ashwell, Jonathan D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783372/
https://ncbi.nlm.nih.gov/pubmed/31527196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900559
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