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Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness

Generation of a self-tolerant but antigen-responsive T cell repertoire occurs in the thymus. Although glucocorticoids are usually considered immunosuppressive, there is also evidence that they play a positive role in thymocyte selection. To address the question of how endogenous glucocorticoids migh...

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Bibliografiske detaljer
Main Authors: Mittelstadt, Paul R., Monteiro, João P., Ashwell, Jonathan D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386828/
https://ncbi.nlm.nih.gov/pubmed/22653054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63067
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