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Glucocorticoids oppose thymocyte negative selection by inhibiting Helios and Nur77
Glucocorticoid signaling in thymocytes shapes the T cell antigen receptor (TCR) repertoire by antagonizing thymocyte negative selection. The transcription factors Nur77 and Helios, which are upregulated in TCR-signaled thymocytes, have been implicated in negative selection. Here we found that glucoc...
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| Udgivet i: | J Immunol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6783372/ https://ncbi.nlm.nih.gov/pubmed/31527196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900559 |
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