Suppression of Dendritic Cell-Derived IL-12 by Endogenous Glucocorticoids Is Protective in LPS-Induced Sepsis

Sepsis, an exaggerated systemic inflammatory response, remains a major medical challenge. Both hyperinflammation and immunosuppression are implicated as causes of morbidity and mortality. Dendritic cell (DC) loss has been observed in septic patients and in experimental sepsis models, but the role of...

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Detalles Bibliográficos
Publicado en:PLoS Biol
Main Authors: Li, Caiyi C., Munitic, Ivana, Mittelstadt, Paul R., Castro, Ehydel, Ashwell, Jonathan D.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595142/
https://ncbi.nlm.nih.gov/pubmed/26440998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002269
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