Suppression of Dendritic Cell-Derived IL-12 by Endogenous Glucocorticoids Is Protective in LPS-Induced Sepsis

Sepsis, an exaggerated systemic inflammatory response, remains a major medical challenge. Both hyperinflammation and immunosuppression are implicated as causes of morbidity and mortality. Dendritic cell (DC) loss has been observed in septic patients and in experimental sepsis models, but the role of...

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Udgivet i:PLoS Biol
Main Authors: Li, Caiyi C., Munitic, Ivana, Mittelstadt, Paul R., Castro, Ehydel, Ashwell, Jonathan D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595142/
https://ncbi.nlm.nih.gov/pubmed/26440998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002269
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