Distinct Domains of the CB1 Cannabinoid Receptor Mediate Desensitization and Internalization

Desensitization of cannabinoid receptor signaling by a G-protein coupled receptor kinase (GRK) was examined using theXenopus oocyte expression system. Application of a CB1 agonist, WIN 55,212-2, evoked a concentration-dependent increase in K(+) conductance (K(ir)3) in oocytes coexpressing rat CB1 wi...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Jin, Wenzhen, Brown, Sean, Roche, John P., Hsieh, Candace, Celver, Jeremy P., Kovoor, Abraham, Chavkin, Charles, Mackie, Ken
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1999
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782730/
https://ncbi.nlm.nih.gov/pubmed/10234009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-10-03773.1999
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