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Prostaglandin E(2) Stimulates Amyloid Precursor Protein Gene Expression: Inhibition by Immunosuppressants

Amyloid plaques that accumulate in the brains of patients with Alzheimer’s disease (AD) are primarily composed of aggregates of amyloid peptides that are derived from the amyloid precursor protein (APP). Overexpression of APP in cell cultures increases the formation of amyloidogenic peptides and cau...

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Bibliografske podrobnosti
izdano v:J Neurosci
Main Authors: Lee, Robert K. K., Knapp, Stefan, Wurtman, Richard J.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 1999
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782137/
https://ncbi.nlm.nih.gov/pubmed/9920657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-03-00940.1999
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