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Prostaglandin E(2) Stimulates Amyloid Precursor Protein Gene Expression: Inhibition by Immunosuppressants

Amyloid plaques that accumulate in the brains of patients with Alzheimer’s disease (AD) are primarily composed of aggregates of amyloid peptides that are derived from the amyloid precursor protein (APP). Overexpression of APP in cell cultures increases the formation of amyloidogenic peptides and cau...

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Vydáno v:J Neurosci
Hlavní autoři: Lee, Robert K. K., Knapp, Stefan, Wurtman, Richard J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 1999
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782137/
https://ncbi.nlm.nih.gov/pubmed/9920657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-03-00940.1999
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