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Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation

Amyloid plaques in Alzheimer disease are primarily aggregates of Aβ peptides that are derived from the amyloid precursor protein (APP). Neurotransmitter agonists that activate phosphatidylinositol hydrolysis and protein kinase C stimulate APP processing and generate soluble, non-amyloidogenic APP (A...

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Bibliografiska uppgifter
Huvudupphovsmän: Lee, Robert K. K., Araki, Wataru, Wurtman, Richard J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences of the USA 1997
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC24694/
https://ncbi.nlm.nih.gov/pubmed/9144253
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