HLA-I Associated Adaptation Dampens CD8 T-Cell Responses in HIV Ad5-Vectored Vaccine Recipients

HLA-I–associated human immunodeficiency virus (HIV) adaptation is known to negatively affect disease progression and CD8 T-cell responses. We aimed to assess how HLA-I–associated adaptation affects HIV vaccine–induced CD8 T-cell responses in 2 past vaccine efficacy trials. We found that vaccine-enco...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Infect Dis
Auteurs principaux: Boppana, Sushma, Sterrett, Sarah, Files, Jacob, Qin, Kai, Fiore-Gartland, Andrew, Cohen, Kristen W, De Rosa, Stephen C, Bansal, Anju, Goepfert, Paul A
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Major Articles and Brief Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782105/
https://ncbi.nlm.nih.gov/pubmed/31301135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiz368
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