Elevated HIV Infection of CD4 T Cells in MRKAd5 Vaccine Recipients Due to CD8 T Cells Targeting Adapted Epitopes

HIV frequently escapes CD8 T cell responses, leading to the accumulation of viral adaptations. We recently demonstrated that during chronic HIV infection, adapted epitopes can promote maturation of dendritic cells (DCs) through direct CD8 T cell interactions and lead to enhanced HIV trans-infection...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Qin, Kai, Boppana, Sushma, Carlson, Jonathan M., Fiore-Gartland, Andrew, Files, Jacob, Zeng, Jie, Edberg, Jeffrey, Mailliard, Robbie B., Ochsenbauer, Christina, Bansal, Anju, Goepfert, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312883/
https://ncbi.nlm.nih.gov/pubmed/34076482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00160-21
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