CD8 T cells targeting adapted epitopes in chronic HIV infection promote dendritic cell maturation and CD4 T cell trans-infection

HIV-1 frequently escapes from CD8 T cell responses via HLA-I restricted adaptation, leading to the accumulation of adapted epitopes (AE). We previously demonstrated that AE compromise CD8 T cell responses during acute infection and are associated with poor clinical outcomes. Here, we examined the im...

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Pubblicato in:PLoS Pathog
Autori principali: Qin, Kai, Boppana, Sushma, Du, Victor Y., Carlson, Jonathan M., Yue, Ling, Dilernia, Dario A., Hunter, Eric, Mailliard, Robbie B., Mallal, Simon A., Bansal, Anju, Goepfert, Paul A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703693/
https://ncbi.nlm.nih.gov/pubmed/31398241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007970
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