Cross-Reactive CD8 T-Cell Responses Elicited by Adenovirus Type 5-Based HIV-1 Vaccines Contributed to Early Viral Evolution in Vaccine Recipients Who Became Infected

Because of HIV’s vast sequence diversity, the ability of the CD8 T-cell response to recognize several variants of a single epitope is an important consideration for vaccine design. Cross-recognition of viral epitopes by CD8 T cells is associated with viral control during HIV-1 infection, but little...

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Bibliographic Details
Published in:J Virol
Main Authors: Boppana, Sushma, Fiore-Gartland, Andrew, Bansal, Anju, Goepfert, Paul
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955250/
https://ncbi.nlm.nih.gov/pubmed/31645444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01632-19
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