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Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cells

BACKGROUND: Synthesis of the hemostatic protein von Willebrand factor (VWF) drives formation of endothelial storage organelles called Weibel‐Palade bodies (WPBs). In the absence of VWF, angiogenic and inflammatory mediators that are costored in WPBs are subject to alternative trafficking routes. In...

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書目詳細資料
發表在:Res Pract Thromb Haemost
Main Authors: Schillemans, Maaike, Kat, Marije, Westeneng, Jurjen, Gangaev, Anastasia, Hofman, Menno, Nota, Benjamin, van Alphen, Floris P. J., de Boer, Martin, van den Biggelaar, Maartje, Margadant, Coert, Voorberg, Jan, Bierings, Ruben
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782018/
https://ncbi.nlm.nih.gov/pubmed/31624792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12242
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