Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cells

BACKGROUND: Synthesis of the hemostatic protein von Willebrand factor (VWF) drives formation of endothelial storage organelles called Weibel‐Palade bodies (WPBs). In the absence of VWF, angiogenic and inflammatory mediators that are costored in WPBs are subject to alternative trafficking routes. In...

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Vydáno v:Res Pract Thromb Haemost
Hlavní autoři: Schillemans, Maaike, Kat, Marije, Westeneng, Jurjen, Gangaev, Anastasia, Hofman, Menno, Nota, Benjamin, van Alphen, Floris P. J., de Boer, Martin, van den Biggelaar, Maartje, Margadant, Coert, Voorberg, Jan, Bierings, Ruben
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Original Articles: Haemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782018/
https://ncbi.nlm.nih.gov/pubmed/31624792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12242
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