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Early-life DNA methylation profiles are indicative of age-related transcriptome changes

BACKGROUND: Alterations to cellular and molecular programs with brain aging result in cognitive impairment and susceptibility to neurodegenerative disease. Changes in DNA methylation patterns, an epigenetic modification required for various CNS functions are observed with brain aging and can be prev...

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Detalles Bibliográficos
Publicado en:Epigenetics Chromatin
Main Authors: Hadad, Niran, Masser, Dustin R., Blanco-Berdugo, Laura, Stanford, David R., Freeman, Willard M.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781367/
https://ncbi.nlm.nih.gov/pubmed/31594536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-019-0306-5
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