Mibefradil, a T‐type Ca(2+) channel blocker also blocks Orai channels by action at the extracellular surface

BACKGROUND AND PURPOSE: Mibefradil, a T‐type Ca(2+) channel blocker, has been investigated for treating solid tumours. However, its underlying mechanisms are still unclear. Here, we have investigated the pharmacological actions of mibefradil on Orai store‐operated Ca(2+) channels. EXPERIMENTAL APPRO...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Br J Pharmacol
Egile Nagusiak: Li, Pengyun, Rubaiy, Hussein N., Chen, Gui‐Lan, Hallett, Thomas, Zaibi, Nawel, Zeng, Bo, Saurabh, Rahul, Xu, Shang‐Zhong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2019
Gaiak:
Research Papers
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6780027/
https://ncbi.nlm.nih.gov/pubmed/31271653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14788
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