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Mibefradil, a T‐type Ca(2+) channel blocker also blocks Orai channels by action at the extracellular surface
BACKGROUND AND PURPOSE: Mibefradil, a T‐type Ca(2+) channel blocker, has been investigated for treating solid tumours. However, its underlying mechanisms are still unclear. Here, we have investigated the pharmacological actions of mibefradil on Orai store‐operated Ca(2+) channels. EXPERIMENTAL APPRO...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6780027/ https://ncbi.nlm.nih.gov/pubmed/31271653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14788 |
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