G-tract RNA removes Polycomb Repressive Complex 2 from genes

Polycomb Repressive Complex 2 (PRC2) maintains repression of cell type-specific genes but also associates with genes ectopically in cancer. While it is currently unknown how PRC2 is removed from genes, such knowledge would be useful for the targeted reversal of deleterious PRC2 recruitment events. H...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Beltran, Manuel, Tavares, Manuel, Justin, Neil, Khandelwal, Garima, Ambrose, John, Foster, Benjamin M., Worlock, Kaylee B., Tvardovskiy, Andrey, Kunzelmann, Simone, Herrero, Javier, Bartke, Till, Gamblin, Steven J., Wilson, Jon R., Jenner, Richard G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778522/
https://ncbi.nlm.nih.gov/pubmed/31548724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0293-z
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