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Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFNγ responsiveness
The type II IFN (IFNγ) enhances antimicrobial activity yet also drives expression of genes that amplify inflammatory responses. Hence, excessive IFNγ stimulation can be pathogenic. Here, we describe a previously unappreciated mechanism whereby IFNγ itself dampens myeloid cell activation. Staining of...
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| Publié dans: | Life Sci Alliance |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Life Science Alliance LLC
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6778285/ https://ncbi.nlm.nih.gov/pubmed/31585982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900447 |
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