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Down regulation of macrophage IFNGR1 exacerbates systemic L. monocytogenes infection
Interferons (IFNs) target macrophages to regulate inflammation and resistance to microbial infections. The type II IFN (IFNγ) acts on a cell surface receptor (IFNGR) to promote gene expression that enhance macrophage inflammatory and anti-microbial activity. Type I IFNs can dampen macrophage respons...
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| 出版年: | PLoS Pathog |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5457163/ https://ncbi.nlm.nih.gov/pubmed/28542482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006388 |
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