Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives nigrostriatal degeneration

Brain expression of AAV-Ifn-γ leads to reactive gliosis, nigrostriatal degeneration and midbrain calcification in wild type mice. This mouse model phenocopies idiopathic basal ganglia calcification which is associated with Parkinsonian symptoms. To understand how the nigro-striatal pathway is select...

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Detaylı Bibliyografya
Yayımlandı:Neurobiol Dis
Asıl Yazarlar: Strickland, Michael R, Koller, Emily J, Deng, Doris Z, Ceballos-Diaz, Carolina, Golde, Todd E, Chakrabarty, Paramita
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748010/
https://ncbi.nlm.nih.gov/pubmed/29196213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.11.007
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