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Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives nigrostriatal degeneration
Brain expression of AAV-Ifn-γ leads to reactive gliosis, nigrostriatal degeneration and midbrain calcification in wild type mice. This mouse model phenocopies idiopathic basal ganglia calcification which is associated with Parkinsonian symptoms. To understand how the nigro-striatal pathway is select...
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| Veröffentlicht in: | Neurobiol Dis |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5748010/ https://ncbi.nlm.nih.gov/pubmed/29196213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.11.007 |
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