Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model

Parkinson’s disease (PD) is characterized by the presence of α-synuclein aggregates known as Lewy bodies and Lewy neurites, whose formation is linked to disease development. The causal relation between α-synuclein aggregates and PD is not well understood. We generated a new transgenic mouse line (MI...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Wegrzynowicz, Michal, Bar-On, Dana, Calo’, Laura, Anichtchik, Oleg, Iovino, Mariangela, Xia, Jing, Ryazanov, Sergey, Leonov, Andrei, Giese, Armin, Dalley, Jeffrey W., Griesinger, Christian, Ashery, Uri, Spillantini, Maria Grazia
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2019
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778064/
https://ncbi.nlm.nih.gov/pubmed/31165254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-02023-x
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