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Evolution of Inosine-specific Endonuclease V from Bacterial DNase to Eukaryotic RNase
Endonuclease V (EndoV) cleaves the second phosphodiester bond 3′ to a deaminated adenosine (inosine). Although highly conserved, EndoV homologs change substrate preference from DNA in bacteria to RNA in eukaryotes. We have characterized EndoV from six different species and determined crystal structu...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6778043/ https://ncbi.nlm.nih.gov/pubmed/31444105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.06.046 |
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