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Evolution of Inosine-specific Endonuclease V from Bacterial DNase to Eukaryotic RNase
Endonuclease V (EndoV) cleaves the second phosphodiester bond 3′ to a deaminated adenosine (inosine). Although highly conserved, EndoV homologs change substrate preference from DNA in bacteria to RNA in eukaryotes. We have characterized EndoV from six different species and determined crystal structu...
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| Publicat a: | Mol Cell |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6778043/ https://ncbi.nlm.nih.gov/pubmed/31444105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.06.046 |
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