Organization of Chromatin by Intrinsic and Regulated Phase Separation

Eukaryotic chromatin is highly condensed yet dynamically accessible to regulation, and organized into subdomains. We demonstrate that reconstituted chromatin undergoes histone tail-driven liquid-liquid phase separation (LLPS) in physiologic salt and when microinjected into cell nuclei, producing den...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Gibson, Bryan A., Doolittle, Lynda K., Schneider, Maximillian W.G., Jensen, Liv E., Gamarra, Nathan, Henry, Lisa, Gerlich, Daniel W., Redding, Sy, Rosen, Michael K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778041/
https://ncbi.nlm.nih.gov/pubmed/31543265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.08.037
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