Intrinsic Disorder and Phase Separation Coordinate Exocytosis, Motility, and Chromatin Remodeling in the Human Acrosomal Proteome

Intrinsic disorder refers to protein regions that lack a fixed three−dimensional structure under physiological conditions, enabling conformational plasticity. This flexibility allows for diverse functions, including transient interactions, signaling, and phase separation via disorder-to-order transi...

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Detalhes bibliográficos
Main Authors: Shivam Shukla, Sean S. Lastorka, Vladimir N. Uversky
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-04-01
Colecção:Proteomes
Assuntos:
proteins
bioinformatics
structure
fertility
reproduction
human sperm
Acesso em linha:https://www.mdpi.com/2227-7382/13/2/16
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