RAD51AP1 is an essential mediator of Alternative Lengthening of Telomeres

Alternative Lengthening of Telomeres (ALT) is a homology-directed repair (HDR) mechanism of telomere elongation that controls proliferation in aggressive cancers. We show that the disruption of RAD51-associated protein 1 (RAD51AP1) in ALT+ cancer cells leads to generational telomere shortening. This...

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書誌詳細
出版年:Mol Cell
主要な著者: Gonzalez, Jonathan Barroso, Exposito, Laura Garcia, Hoang, Song My, Lynskey, Michelle Lee, Roncaioli, Justin L., Ghosh, Arundhati, Wallace, Callen T., Modesti, Mauro, Bernstein, Kara A., Sarkar, Saumendra N., Watkins, Simon C., O’Sullivan, Roderick J.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778027/
https://ncbi.nlm.nih.gov/pubmed/31400850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.06.043
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