RAD51AP1 is an essential mediator of Alternative Lengthening of Telomeres

Alternative Lengthening of Telomeres (ALT) is a homology-directed repair (HDR) mechanism of telomere elongation that controls proliferation in aggressive cancers. We show that the disruption of RAD51-associated protein 1 (RAD51AP1) in ALT+ cancer cells leads to generational telomere shortening. This...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Gonzalez, Jonathan Barroso, Exposito, Laura Garcia, Hoang, Song My, Lynskey, Michelle Lee, Roncaioli, Justin L., Ghosh, Arundhati, Wallace, Callen T., Modesti, Mauro, Bernstein, Kara A., Sarkar, Saumendra N., Watkins, Simon C., O’Sullivan, Roderick J.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778027/
https://ncbi.nlm.nih.gov/pubmed/31400850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.06.043
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