Adipocyte JAK2 mediates spontaneous metabolic liver disease and hepatocellular carcinoma

Nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are liver manifestations of the metabolic syndrome and can progress to hepatocellular carcinoma (HCC). Loss of growth hormone (GH) signaling is reported to predispose to NAFLD and NASH through direct actions on the liver. Here, we r...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Corbit, Kevin C., Wilson, Camella G., Lowe, Dylan, Tran, Jennifer L., Vera, Nicholas B., Clasquin, Michelle, Mattis, Aras N., Weiss, Ethan J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777921/
https://ncbi.nlm.nih.gov/pubmed/31393852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131310
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