Adipocyte JAK2 mediates spontaneous metabolic liver disease and hepatocellular carcinoma

Nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are liver manifestations of the metabolic syndrome and can progress to hepatocellular carcinoma (HCC). Loss of growth hormone (GH) signaling is reported to predispose to NAFLD and NASH through direct actions on the liver. Here, we r...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Corbit, Kevin C., Wilson, Camella G., Lowe, Dylan, Tran, Jennifer L., Vera, Nicholas B., Clasquin, Michelle, Mattis, Aras N., Weiss, Ethan J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777921/
https://ncbi.nlm.nih.gov/pubmed/31393852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131310
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